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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nifdc.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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丹参注射液有效成分的确定及不同厂家中量效关系的比较

Identification of active ingredients and dose-response relationship of Danshen injection from different manufacturers

分类号:
出版年·卷·期(页码):2014,34 (3):0-0
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的:确定丹参注射液的主要活性成分,研究丹参注射液主要有效成分和生物活性之间的关系,为其质量标准的提高提供实验数据。方法:采用外标法测定丹参注射液中原儿茶醛、丹参素钠、迷迭香酸和丹酚酸B的含量。采用家兔体外血小板聚集实验对不同厂家多个批次的丹参注射液进行活性测定。结果:不同厂家生产的丹参注射液中主要物质的含量及生物活性的差异较大。丹参注射液的生物活性主要与丹参素钠、原儿茶醛及迷迭香酸的含量呈正相关,丹参注射液中丹参素钠的含量对其生物活性的高低起主要作用。结论:丹参注射液的主要活性成分包含丹参素钠、原儿茶醛及迷迭香酸。

-----英文摘要:---------------------------------------------------------------------------------------

Objective: To identify the main active components of Danshen injection,and find out the relationship between active ingredients and biological activity as well so as to provide experimental data for improvement of the quality standard. Methods: An external standard method was used to determine the contents of salvia sodium,protocatechuicaldehyde,rosmarinic acid and salvianolic acid B. The biological activities of different batches of Danshen injection were measured by rabbit platelet aggregation test. Results: There were big differences in major material contents and biological activity of Danshen injection from different manufacturers. The biological activity of Danshen injection was positively correlated to the contents of salvia sodium,protocatechuicaldehyde and rosmarinic acid. The content of salvia sodium played a major role of the biological activity of Danshen injection. Conclusion: The main active ingredients of Danshen injection include salvia sodium,protocatechuicaldehyde and rosmarinic acid.

-----参考文献:---------------------------------------------------------------------------------------
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[6] LI An-ping(李安平), YANG Xi(杨锡), DING Yong-hui(丁永辉), et al. HPLC method for simultaneous measurement of seven water-soluble ingredients with single marker in Danshen injection(一测多评HPLC法测定丹参注射液中7个水溶性成分含量)[J]. Chin J Pharm Anal (药物分析杂志), 2012, 32(9):1534
[7] CHEN Chen(陈晨), LIU Qian(刘倩), ZHANG Yuan(张媛), et al. Screening of bioactivity assay methods of safflower injection(红花注射液生物活性测定方法的筛选)[J]. Chin J Pharm Anal(药物分析杂志), 2013, 33(1):12
[8] LIU Qian(刘倩), CHEN Chen(陈晨), DAI Zhong(戴忠), et al. Active ingredient identification and dose response relationship comparison for the safflower injection from different manufactures(红花注射液有效成分的确定及不同厂家中量效关系的比较)[J]. Chin J Pharm Anal(药物分析杂志), 2012, 32(7):1158
[9] YOU Yong-ji(游勇基), CHENG Guang-qiang(程广强), CHEN Ming-hui(陈铭辉). Simultaneous determination of Danshensu, protocatechuic acid protocatechuic aldehyde and salviamolic acid B in salvia miltiorrhiza injection(丹参注射剂中丹参素、原儿茶酸、原儿茶醛和丹酚酸B的同时测定)[J]. Chin J Pharm Anal(药物分析杂志), 2004, 24(1):46
[10] ZHANG Qing-lian(张青莲), ZHU Ya-yan(朱雅艳), XU Mei-hua(徐美华).Quality inspection of Danshen injection from different manufacturers(不同厂家丹参注射液的质量考察)[J]. Strait Pharm J(海峡药学), 2013, 25(5):44
[11] LI Xue-lin(李学林), YAO Bao-jie(姚保杰), LI Chun-xiao(李春晓).Research progress of salvia and its preparations on platelet function(丹参及其制剂对血小板功能影响的研究进展)[J]. China Pharm(中国药房), 2013, 24(7):670
[12] GAO Chong(高冲), LIU Lu(刘璐), HU Ai-ju(胡爱菊), et al. Research progress in pharmacological study on Chinese materia medica with the function of activating blood and resolving stasis(活血化瘀中药的药理作用研究进展)[J]. Drug Eval Res(药物评价研究), 2013, 36(1):64

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