关闭
 
读者在线:用户名 密码
首页 期刊简介 投稿须知 期刊目录 专家风采 编委会 特邀顾问 联系我们 移动出版
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5



刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nifdc.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

访问统计
您是第  8 0 1 6 3 9 5 位浏览者
您当前的位置:首页 >> 正文

盐酸度洛西汀的波谱学特征和结构确证

Spectral characteristic analysis and structure identification of duloxetine hydrochloride

分类号:
出版年·卷·期(页码):2013,33 (6):0-0
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的: 建立利用分析仪器确证盐酸度洛西汀化学结构的方法。 方法: 通过元素分析仪分析盐酸度洛西汀的元素组成,运用旋光仪测定其旋光性,并利用核磁共振(NMR)、质谱(MS)、红外光谱(IR)、差热(DSC)、X-射线粉末衍射对盐酸度洛西汀进行结构分析。 结果: 通过实验证实盐酸度洛西汀的结构为(+)-(S)-N-甲基-γ-(1-萘氧基)-2-噻吩丙胺盐酸盐。 结论: 该方法准确可行,可为盐酸度洛西汀的结构鉴定提供依据。

-----英文摘要:---------------------------------------------------------------------------------------

Objective: To establish a method for the determination of the chemical structure of duloxetine hydrochloride by analytical instruments. Methods: The elemental analyzer was adopted to analyze the elemental composition of duloxetine hydrochloride and the polarimeter for determining its optical rotation.Nuclear magnetic resonance(NMR),mass spectrometry(MS),infrared spectrometry(IR),differential scanning calorimeter(DSC)and X-ray powder diffraction were adopted to analyze the chemical structure of duloxetine hydrochloride. Results: The chemical structure of duloxetine hydrochloride was (+)-(S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine hydrochloride. Conclusion: The method is accurate,practical and can provide a comprehensive reference for structural identification of duloxetine hydrochloride.

-----参考文献:---------------------------------------------------------------------------------------
1 Monteleone F,Caputo M,Capasso A,et al.Duloxetine in the treatment of depression:an overview.Cent Nerv Syst Agent Med Chem,2011,11(3):174
2 Martiny K,Refsgaard E,Lund V,et al.A 9-week randomized trial comparing a chronotherapeutic intervention (wake and light therapy)to exercise in major depressive disorder patients treated with duloxetine.J Clin Psychiatry,2012,73(9):123
3 Bernauer M,Wu N,Chen SY,et al.Use of select medications prior to duloxetine initiation among commercially-insured patients.J Pain Res,2012,(8)5:271
4 Karaiskos D,Tzavellas E,Spengos K,et al.Duloxetine versus citalopram and sertraline in the treatment of poststroke depression,anxiety,and fatigue.J Neuropsychiatry Clin Neurosci,2012,24(3):349
5 ChP(中国药典).2010.Vol Ⅰ(一部):Appendix(附录)Ⅴ C
6 Suzuki Y,Iwata M,Shibasaki M,et al.Concise enantioselective synthesis of duloxetine via direct catalytic asymmetric aldol reaction of thioamide.J Org Chem,2012,77(9):4496
7 CHAI Yu-zhu(柴雨柱),CHEN Guo-hua(陈国华),WANG Li(王丽), et al.Synthesis of antidepressant drug duloxetine hydrochloride(抗抑郁药盐酸度洛西汀的合成).Chin J Mod Appl Pharm (中国现代应用药学),2007,24(3):209
8 Sevgi TU.Determination and validation of duloxetine hydrochloride in capsules by HPLC with pre-column derivatization and fluorescence detection.J Chromatogr Sci,2012,50(6):494
9 XIN Yu-feng(辛玉峰),QU Xiao-hua(曲晓华).Structural confirmation of cefozopran hydrochloride(盐酸头孢唑兰的结构确证).Chin J Pharm Anal(药物分析杂志),2011,31(3):433
10 ChP(中国药典).2010.VolⅡ(二部):Appendix(附录)ⅦC
11 NING Yong-cheng(宁永成).Structural Identification of Organic Compoundsand Organic Spectroscopy(有机化合物结构鉴定与有机波谱学研究).2nd Ed(第二版).Beijing(北京):Science Press(科学出版社),2001.269
12 ZHU Huai-wu(朱淮武).The Spectra Analysis on Structure of Organic Compound Molecule(有机分子结构波谱解析).Beijing(北京):Chemical Industry Press(化学工业出版社),2005.91

欢迎阅读《药物分析杂志》!您是该文第 1215位读者!

药物分析杂志 © 2009
地址:北京天坛西里2号 邮政编码:100050; 电子邮件:ywfx@nicpbp.org.cn

本系统由北京博思汇文数字科技有限公司设计开发 技术服务电话:010-60213898