关闭
 
读者在线:用户名 密码
首页 期刊简介 投稿须知 期刊目录 专家风采 编委会 特邀顾问 联系我们 移动出版
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5



刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

访问统计
您是第  6 1 6 7 3 0 9 位浏览者
您当前的位置:首页 >> 正文

红花注射液有效成分的确定及不同厂家中量效关系的比较

Active ingredient identification and dose response relationship comparison for the safflower injection from different manufacturres

分类号:
出版年·卷·期(页码):2012,32 (7):0-0
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的: 确定红花注射液的主要活性成分,研究红花注射液主要有效成分和生物活性之间的关系,为其质量标准的提高提供实验数据。 方法: 采用体内、体外方法对羟基红花黄色素A(HSYA)含量和总黄酮含量不同的红花注射液进行活性测定。 结果: 当总黄酮含量基本一致时(0.57 mg·mL-1),随着HSYA含量的降低,抗小鼠体内血栓形成的保护率、家兔体外血小板聚集抑制率随之降低;当HSYA含量基本一致时(0.17~0.21 mg·mL-1),随着总黄酮含量的降低,抗血栓形成的保护率和血小板聚集抑制率也随之降低;而当红花注射液中HSYA和总黄酮的含量均低于另一红花注射液中HSYA和总黄酮的含量时,其抗血栓形成保护率和血小板抑制率也随之降低。 结论: 红花注射液主要活性成分为HSYA和总黄酮,二者在生物活性上具有协同作用,含量与生物活性成正相关。

-----英文摘要:---------------------------------------------------------------------------------------

Objective: To identify the main active components of safflower injection, as well find out the relationship between active ingredients and biological activities so that provide the experimental data to improve the quality standard. Methods: Measure the biological activities of safflower injection by in vivo/in vitro assays, which contain different concentrations of hydroxysafflor yellow A(HSYA) and total flavonoids. Results: With the same content of total flavonoid (0.57 mg·mL-1), the protective effects are decreased in thrombus formation in mice and platelet aggregation rate in vitro with the content of HSYA reduced, while with the same content of HSYA(between 0.17 mg·mL-1 and 0.21 mg·mL-1), the protection effects are declined in thrombus formation in mice and the rabbit platelet aggregation rate in vitro with the content of total flavonoids reduced. At the same time, when the contents of HSYA and total flavonoid in safflower injection are both lower than that of another one, then the protective effects are also lower. Conclusion: The main active ingredients of safflower injection are HSYA and total flavonoids, which have synergistic effect on biological activity. In additional, there is a positive correlation between the contents of HSYA and total flavonoids and biological activity.

-----参考文献:---------------------------------------------------------------------------------------
1 ZHANG Qing-hua(张清华).Productive technology control of safflower injection quality stability(红花注射液质量稳定性的生产工艺控制).Shanxi Chem Ind(山西化工),2005,25(1):37
2 TIAN Dai-hua(田代华).Practical Dictionary of Chinese Medicine(实用中药辞典).Vol Ⅰ(上卷).Beijing(北京):People's Medical Publishing House(人民卫生出版社),2002.812
3 CHEN Qi(陈奇).Chinese Pharmacology Research Methodology(中药药理学研究方法学).2nd Ed(第二版).Beijing(北京):People's Medical Publishing House(人民卫生出版社),2006.566,570
4 LIANG Xiao-tian(梁晓天).Commonly Used Chinese Medicine Basic Research(常用中药基础研究).Vol Ⅱ(第二卷).Beijing(北京):Science Press(科学出版社),2004.102
5 RUI Jing(芮菁),HAN Jing(韩晶),TANG Yuan-tai(唐元泰).Comparison in bioactivity of breviscapine injections with different origins(不同来源灯盏花素注射液"生物活性"质量的比较研究).Drug Stand China(中国药品标准),2007,8(4):12
6 XIE Hui(谢辉),XU Hui-qin(许惠琴),LI Hong(李虹).The effect to mice clotting time and antithrombotic acticity of Allium macrostemon Bunge extraction(薤白提取物对小鼠凝血时间及体内血栓形成的影响).Lishizhen Med Mater Med Res(时珍国医国药),2004,15(12):811
7 ZHOU Jian(周剑),LIU Rong-hua(刘荣华),LI Xiang(李祥).The effect of safflower to rabbit platelet aggregation with ADP inducement(红花对ADP给药血小板家兔聚集率的影响).Asia-Pacific Tradit Med(亚太传统医药),2008,4(3):50

欢迎阅读《药物分析杂志》!您是该文第 937位读者!

药物分析杂志 © 2009
地址:北京天坛西里2号 邮政编码:100050; 电子邮件:ywfx@nicpbp.org.cn

本系统由北京博思汇文数字科技有限公司设计开发 技术服务电话:400-921-9838