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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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四味抗痨丸质量标准研究

Study on determination method of quality control for Siweikanglao pills

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出版年·卷·期(页码):2012,32 (6):0-0
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的: 建立四味抗痨丸的质量控制标准。 方法: 利用薄层色谱法对四味抗痨丸处方中的白芍、大黄、巴豆进行定性鉴别;采用高效液相色谱法测定四味抗痨丸中芍药苷的含量。色谱条件:以十八烷基硅烷键合硅胶为填充剂;以乙腈-0.1%磷酸溶液(14∶86)为流动相;检测波长为230 nm;柱温30 ℃;流速为1.0 mL·min-1;进样量为10 μL。 结果: 白芍、大黄、巴豆采用相应的薄层鉴别方法,薄层展开后均显示与对照药材相同的特异性斑点,分离效果好。芍药苷质量在2.55×10﹣3μg~0.51 μg范围内与峰面积有良好的线性关系。平均回收率为97.5%,RSD为0.57%。 结论: 该方法准确、可靠、专属性强,为建立四味抗痨丸质量控制标准提供依据。

-----英文摘要:---------------------------------------------------------------------------------------

Objective: To establish a quality standard of Siweikanglao pills. Method: Traditional Chinese medicine in prescription such as herbal Paeonia lactiflora Pall.、Rheum officinale Baill.Croton tiglium L were identified by a series of TLC methods.The content of paeoniforin in Siweikanglao pills was determined by HPLC method.Phenomenex column was adopted with the mobile phase consisted of acetonitrile-0.1%phosphoric acid(14∶86) at flow rate of 1.0 mL·min-1,the UV detection wavelength was 230 nm,and the volume of injection was 10 μL. Results: Three methods were established for the identification of Paeonia lactiflora Pall. Rheum officinale Baill.Croton tiglium L with TLC.The principal spot in the chromatogram obtained with the test solution was similar in position,colour and size to the principal spot in the chromatogram obtained with the reference solution.The linear range of stachydrine hydrochloride was within the range of 2.55×10-3-0.51 μg.The average recovery was 97.5% and the RSD was 0.57%. Conclusion: The method is accurate,reliable and specific,and can be used for the quality control of Siweikanglao pills.

-----参考文献:---------------------------------------------------------------------------------------
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11 PENG Yuan-gui(彭源贵),WANG Yan-qiang(王宴强),XIE Zhao-ming(谢昭明).Studies on the quantitative analysis of multi-index components in Shenrongbaifeng Gao(参茸白风膏多指标成分定量分析).Hunan Guiding J Tradit Chin Med Pharmcol (湖南中医药导报),1998,2(4):28
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