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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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仿生提取-电感耦合等离子体质谱法测定含朱砂中药制剂中可溶性汞含量

Determination of leachable mercury in Chinese traditional patent medicine containing cinnabar by bionic extraction-ICP-MS

分类号:
出版年·卷·期(页码):2012,32 (6):0-0
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的: 建立仿生提取-电感耦合等离子体质谱技术(ICP-MS)测定含朱砂中药制剂中可溶性汞含量的分析测定方法。 方法: 通过模拟人体胃肠道环境,采用人工胃液提取含朱砂中药制剂中的可溶性汞,结合ICP-MS进行分析测定。 结果: 该方法操作简便、灵敏。方法回收率为98.8%,检出限为0.20 μg·L-1,重复性良好(RSD=4.1%)。 结论: 通过对实际样品的测定,该方法可用于含朱砂中药制剂中可溶性汞含量的测定。

-----英文摘要:---------------------------------------------------------------------------------------

Objective: To establish a method for determination of the leachable mercury in Chinese traditional patent medicine containing cinnabar by bionic extraction-ICP-MS. Method: Through simulating stomach condition,the leachable mercury was extracted by artificial gastric juice and detected by ICP-MS. Result: The method was simple,sensitive,accurate,and the mean recovery was 98.8%,the detection limit was 0.20 μg·L-1,the precision was calculated of 4.1%(RSD). Conclusion: The developed method is simple,sensitive,accurate,and was suitable for the determination of leachable mercury in Chinese traditional patent medicine containing cinnabar.

-----参考文献:---------------------------------------------------------------------------------------
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3 ZHU Kun-jie(朱坤杰),SUN Jin-ning(孙建宁),ZHANG Shuo-feng(张硕峰),et al.Effect of Angong Niuhuang Pill and the heavy metal constituents on EcoG of brain damage in rats caused by LPS(安宫牛黄丸及重金属组分对内毒素脑损伤大鼠脑电图的影响).Chin Tradit Pat Med(中成药),2008,30(2):178
4 ZHAO Yong(赵雍),CAO Chun-yu(曹春雨),WANG Xiu-rong(王秀荣) et al.Effect of Angong Niuhuang Pill Containing or Not Containing Cinnaba and Realgar on Cerebral Focal Ischemia in Rats(含与不含朱砂和雄黄的安宫牛黄丸对大鼠局灶性脑缺血的影响).Chin J Integr Tradit West Med(中国中西医结合杂志),2002,22(9):684
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6 FENG Shu-yi(冯淑怡),SUN Jian-ning(孙建宁).Research of Protective Effect on Intracranial Hemorrhage Rat Model of Angong Niuhuang Pill and Its Simplified Prescription(安宫牛黄丸原方及简方对脑出血大鼠损伤保护作用的研究).Prog Mod Biomed(现代生物医学进展),2007,7(4):571
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8 TIAN Nan-hui(田南卉),YANG Guo-hong(杨国红).The research on the content of dissoluble mercury saltsin processed cinnabar determined by atomic absorption spectrometry(原子吸收分光光度法测定炮制朱砂中可溶性汞含量).Chin J Pharm Anal(药物分析杂志),1995,15(1):27

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