关闭
 
读者在线:用户名 密码
首页 期刊简介 投稿须知 期刊目录 专家风采 编委会 特邀顾问 联系我们 移动出版
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5



刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nifdc.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

访问统计
您是第  7 3 1 6 1 9 1 位浏览者
您当前的位置:首页 >> 正文

一测多评法测定速效救心丸中冰片的含量

Determination of borneol in Suxiao Jiuxin pills by quantitative analysis of multi-components by single-marker

分类号:
出版年·卷·期(页码):2012,32 (5):0-0
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

目的: 建立速效救心丸中异龙脑、左旋龙脑、右旋龙脑的一测多评含量测定方法。 方法: 采用手性毛细管柱(30.0 m×0.25 mm×0.25 μm),载气为氮气,FID检测器,柱温为120 ℃,柱流量为1.0 mL·min-1。以正十四烷为内标物,以右旋龙脑为参照物建立其与异龙脑、左旋龙脑的相对校正因子,并进行含量测定,实现一测多评。同时与现行标准的测定结果进行比较以验证一测多评法的准确性。 结果: 所建立的校正因子重现性良好,采用一测多评法的测定结果与现行标准方法的测定结果基本一致。 结论: 所建立的方法能测定以各种冰片投料生产的速效救心丸中的冰片含量。

-----英文摘要:---------------------------------------------------------------------------------------

Objective: To establish a GC method for simultaneous assay of isoborneol, L-borneol and D-borneol in Suxiao Jiuxin pills by quantitative analysis of multi-components by single-marker(QAMS). Methods: A chiral capillary column (30.0 m×0.25 mm×0.25 μm) was adopted, with nitrogen as carrier gas and FID as detector. The temperature of the column was set at 120 ℃ and the flow rate was 1.0 mL·min-1. Tetradecane was used as the internal standard. The ratio of calibration factor of isoborneol and L-borneol to that of D-borneol was calculated respectively to get each relative calibration factors. And the contents of borneol in Suxiao Jiuxin pills were calculated by the relative calibration factor to realize QAMS. The accuracy of this method was affirmed by comparison of the results to that determined by the current standards. Results: The reproducibility of relative calibration factor was perfect and the results calculated by QAMS were consistent with that determined by the current standards. Conclusion: This method can be used to determine borneol in Suxiao Jiuxin pills produced by various kinds of borneols.

-----参考文献:---------------------------------------------------------------------------------------
1 Drug Specifications of Chinese Traditional Patent Formulation Promulgated by the Ministry of Public Health,P R China. Vol 18(卫生部药品标准《中药成方制剂》第十八册).1998.294
2 CHEN Dong-fen(陈冬芬),JIN Zhang-zhao(金樟照),WU Wen-jun(吴文军).Simultaneous GC determination of α-pinene,(+)borneol,(-)borneol in Bingqiao oil(毛细管气相色谱法同时测定冰翘油中α-蒎烯、龙脑和异龙脑的含量).Chin J Pharm Anal(药物分析杂志),2008,28(11):1877
3 XIANG Ling-fei(项凌飞),ZHANG Run-rong(张润容),CHEN Hai-yan(陈海燕).Determination of different compound in Baishuzhen oil by capillary GC(毛细管气相色谱法对百树真油中多种成分的含量测定).Chin J Pharm Anal(药物分析杂志),2009,29(7):1187
4 ZHU Xiao-hong(朱小红),MENG Xin-fang(孟新芳),LIU Fang(刘芳),et al.GC-FID quantitative determination of borneol in compound indomethacin suppositories(气相色谱法测定吲哚美辛三七冰片栓中冰片的含量).Chin J Pharm Anal(药物分析杂志),2006,26(11):1615
5 ZHU Bing-hui(朱炳辉),LIANG Yi-ying(梁艺英),MO Jin-yuan(莫金垣).Identification of Meipian, Aipian((-)borneol) and Bingpian(synthetic borneol) in three species of Chinese patent medicines by chiral capillary gas chromatography(3种中成药中梅片、艾片和合成冰片的手性毛细管气相色谱法鉴别).Chin J Pharm Anal(药物分析杂志),1999,19(3):187
6 WEI Xiao-shu(魏晓舒),HU Ying-juan(胡英娟).Determination of borneol in compound danshen tablets by capillary gas chromatography(毛细管气相色谱法测定复方丹参片中冰片含量).Chin J Pharm Anal(药物分析杂志),2005,25(12):1565
7 JIANG Guang-chi(江光池),FENG Xu-jun(冯旭军),HUANG Lan(黄岚),et al.Pharmacological effects of borneol and isoborneol in mice and rabbits(龙脑和异龙脑对小鼠和家兔的药理作用).West China J Pharm Sci(华西药学杂志),1989,4(1):23
8 WU Qi(吴琦),YANG Xiu-wei(杨秀伟).GC-MS analysis of essential oil from rhizomes of Ligusticum chuanxiong cultivated in GAP base for Chinese medicinal materials of China(国家中药材GAP基地产川芎挥发油化学成分的GC-MS分析).China J Chin Mater Med(中国中药杂志),2008,33(3):276

欢迎阅读《药物分析杂志》!您是该文第 1676位读者!

药物分析杂志 © 2009
地址:北京天坛西里2号 邮政编码:100050; 电子邮件:ywfx@nicpbp.org.cn

本系统由北京博思汇文数字科技有限公司设计开发 技术服务电话:010-60213898