酒石酸美托洛尔片假药的鉴别
Identification of counterfeit metoprolol tartreate tablets
分类号：
出版年·卷·期（页码）：2011,31 (2):0-0
DOI:
10.16155/j.0254-1793.2017.01.01
-----摘要：-------------------------------------------------------------------------------------------
目的: 鉴别酒石酸美托洛尔片中的掺假成分。 方法: 采用HPLC-MS/MS和HPLC-DAD方法对样品中的掺假成分进行分析检测。 结果: 样品中的掺假成分鉴定为氯霉素,抽样的2批标示为酒石酸美托洛尔片样品中,未含酒石酸美托洛尔而含有氯霉素。 结论: 由于氯霉素的紫外光谱图和化学反应现象与酒石酸美托洛尔相似,故极少数据采用氯霉素冒充酒石酸美托洛尔生产假药。
-----英文摘要：---------------------------------------------------------------------------------------
Objective: To identify an unknown component in counterfeit metoprolol tartreate tablets. Methods: To identify the unknown component in samples marked metoprolol tartreate tablets by the high performance liquid chromatography-quadrupole mass spectrometry and HPLC-DAD method. Results: The unknown component in samples marked metoprolol tartreate tablets is not metoprolol tartreate but chloramphenicol. Conclusion: Chloramphenicol illegally added into the metoprolol tartreate tablets to substitute metoprolol tartreate by criminals for UV spectrum and chemical character of chloramphenicol is similar to those of metoprolol tartreate.
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