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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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N-亚硝胺类基因毒性杂质毒性与检测方法研究进展

Research progress on toxicity and detection methods of N-nitrosamines genotoxic impurities

分类号:R917
出版年·卷·期(页码):2020,40 (1):83-89
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

基因毒性杂质能够损伤DNA,造成DNA突变,致癌,严重危害人类健康。本文主要针对基因毒性杂质中的N-亚硝胺类化合物,介绍其毒理学研究进展以及食品、水体、烟草、药品等不同基质中检测方法的研究进展,包括毒理学作用机制、前处理方法、定量方法等,旨在为药品基质中N-亚硝胺类化合物的检测研究提供参考。

-----英文摘要:---------------------------------------------------------------------------------------

Genotoxic impurities can lead to structural damage of DNA,DNA mutation or even cancer,which can greatly damage the health of human. N-nitrosamines is a category of genotoxic impurities. This article describes research advances on toxicological study and various detection methods of N-nitrosamines in various matrix,such as food,water,tobacco and medicines. Toxicological mechanism,sample pretreatment procedures and quantitative methods are also discussed. This article can provide references for the detection method development of N-nitrosamines in medicines.

-----参考文献:---------------------------------------------------------------------------------------

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