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刊物信息

期刊名称:药物分析杂志
主管单位:中国科学技术协会
主办单位:中国药学会
承办:中国食品药品检定研究院
主编:金少鸿
地址:北京天坛西里2号
邮政编码:100050
电话:010-67012819,67058427
电子邮箱:ywfx@nicpbp.org.cn
国际标准刊号:ISSN 0254-1793
国内统一刊号:CN 11-2224/R
邮发代号:2-237
 

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一测多评法在中药中的应用及研究进展

Application and research progress of QAMS in traditional Chinese medicine

分类号:R917
出版年·卷·期(页码):2019,39 (11):1968-1979
DOI: 10.16155/j.0254-1793.2017.01.01
-----摘要:-------------------------------------------------------------------------------------------

一测多评法(QAMS法)是一种多指标同步质量控制方法,它先确定待测样品中有代表性成分的含量,然后根据相对校正因子(RCF)计算待测样品中其他多种成分的含量。目前,各种药品的质量控制和中药现代化都对中药标准的研究和质量控制提出了更高的要求,QAMS作为一种经济、准确的方法,在中药材及其制剂的含量测定中已得到推广应用。自一测多评法提出至今,已有500多篇论文,涉及到药材中多种活性成分的测定、不同制剂中活性成分的测定、药材中某些化学物质的含量测定等。本文对QAMS法的原理、特点、技术要求以及影响因素进行了具体的综述,对近些年QAMS的应用及研究进展进行探讨分析,并展望了QAMS的应用未来,为QAMS质量评价模式在中药分析领域中的进一步研究和应用提供参考。

-----英文摘要:---------------------------------------------------------------------------------------

Quantitative analysis of multi-components by single-marker (QAMS) is a method for detecting multiple components by using an internal reference substance.The requirements in the quality control of various drugs and the modernization of traditional Chinese medicine (TCM) are increasing.Due to its advantage of accuracy and economy, QAMS has been applied in the content determination in Chinese material medica and its preparations.Since the advent of the multi-evaluation method, there have been nearly 500 articles involving the determination of various active ingredients in medicinal materials, the chemical components in different preparations, and certain substances in medicinal materials.In this paper, the principle, characteristics, technical requirements and influencing factors of QAMS method are reviewed in detail.The application and research progress of QAMS in recent years are discussed and analyzed. The future application of the model is prospected, which provides reference for the further research and application of the model in the field of TCM analysis.

-----参考文献:---------------------------------------------------------------------------------------

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